2024 PN NCLEX Questions Nursing Practice Question
In infants and children, the side effects of first-generation over-the-counter (OTC) antihistamines, such as diphenhydramine (Benedryl) and hydroxyzine (Atarax), can include:
Correct Answer: C
Rationale: First-generation OTC antihistamines like diphenhydramine and hydroxyzine can cause paradoxical CNS stimulation in infants and children, leading to increased agitation, hyperactivity, or insomnia instead of sedation.
Option A, Reye's syndrome, is associated with aspirin use, not antihistamines.
Option B, cholinergic effects, such as increased salivation or sweating, are not typical side effects of these antihistamines; instead, they usually have anticholinergic properties.
Option D, nausea and diarrhea, can occur but are not specific or common side effects of first-generation antihistamines in this age group.