2024 PN NCLEX Questions Nursing Practice Question
Distribution of a drug to various tissues depends on the amount of cardiac output to each type of tissue. Which tissue would receive the highest amount of cardiac output and thus the highest amount of a drug?
Correct Answer: D
Rationale: The myocardium receives the highest amount of cardiac output due to its critical role in pumping blood throughout the body. It requires a continuous and substantial blood supply to function effectively, leading to a higher distribution of drugs administered systemically.
Skin (A) receives less cardiac output compared to vital organs, making it a lower priority for drug distribution. Adipose tissue (B) has a lower perfusion rate, resulting in less immediate drug exposure. Skeletal muscle (C), although well-vascularized, does not receive as much blood flow as the myocardium during rest, limiting drug distribution. Thus, the myocardium is prioritized for drug delivery due to its essential physiological demands.