2024 PN NCLEX Questions Nursing Practice Question
A client has been taking a drug (Drug A) that is highly metabolized by the cytochrome p-450 system. He has been on this medication for 6 months. At this time, he is started on a second medication (Drug B) that is an inducer of the cytochrome p-450 system. You should monitor this client for:
Correct Answer: C
Rationale: Monitoring for decreased therapeutic effects of Drug A is essential because the induction of the cytochrome P-450 system by Drug B increases the metabolism of Drug A, leading to lower drug levels and reduced efficacy.
Option A is incorrect as increased therapeutic effects of Drug A are unlikely due to the induction effect.
Option B is not applicable; while Drug B may have increased metabolism, it is not directly affected by Drug A's metabolism.
Option D is also incorrect because Drug B's therapeutic effects are not expected to decrease; rather, they may remain unchanged or increase depending on its own pharmacokinetics.