Pharmacy Technician Certification Exam Practice Question
Which of the following medications has a narrow therapeutic index and requires serum concentrations to be monitored to prevent harm?
Correct Answer: D
Rationale: Carbamazepine is a medication with a narrow therapeutic index, meaning that the difference between effective and toxic doses is small. Monitoring serum concentrations is essential to avoid adverse effects such as toxicity or therapeutic failure.
Carvedilol (A) is a beta-blocker with a wider therapeutic range and does not require routine serum monitoring. Citalopram (B), an antidepressant, also has a broader therapeutic window, although some monitoring may be necessary for specific cases. Clindamycin (C), an antibiotic, does not require serum level monitoring, as its therapeutic index is sufficiently wide. Thus, only Carbamazepine necessitates careful serum concentration monitoring to ensure safety and efficacy.
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