Pharmacy Technician Certification Exam Practice Questions Practice Question

Correct Answer: A

Rationale: Grapefruit juice interacts significantly with certain medications by inhibiting enzymes that metabolize them, leading to increased drug levels in the body. Simvastatin, a cholesterol-lowering medication, is particularly affected, as elevated levels can heighten the risk of serious side effects, including muscle damage.

In contrast, ibuprofen, lisinopril, and doxycycline do not have clinically significant interactions with grapefruit juice. Ibuprofen is a non-steroidal anti-inflammatory drug, lisinopril is an ACE inhibitor for hypertension, and doxycycline is an antibiotic; none of these are metabolized by the same pathways affected by grapefruit juice.